The impact of vitamin K2 and native vitamin D supplementation on vascular calcification in pediatric patients on regular hemodialysis. A randomized controlled trial (2024)

References

Pilar S, Chin Y, Yiwen L, Leilani E, Sadia A, Anne P, et al. Arterial “inflammaging” drives vascular calcification in children on dialysis. Kidney Int. 2019;95:958–72.
Article Google Scholar
London G, Guerin A, Marchais S, Métivier F, Pannier B, Adda H. Arterial media calcification in end-stage renal disease: impact on all-cause and cardiovascular mortality. NDT. 2003;18:1731–40.
PubMed Google Scholar
Russo D, Corrao S, Battaglia Y, Andreucci M, Caiazza A, Carlomagno A, et al. Progression of coronary artery calcification and cardiac events in patients with chronic renal disease not receiving dialysis. Kidney Int. 2011;80:112–18.
Article CAS Google Scholar
Paloian N, Giachelli C. A current understanding of vascular calcification in CKD. Am J Physiol Ren Physiol. 2014;307:F891–F900.
Article CAS Google Scholar
Blacher J, Guerin AP, Pannier B, Marchais SJ, London GM. Arterial calcifications, arterial stiffness, and cardiovascular risk in end-stage renal disease. Hypertension. 2001;38:938–42.
Article CAS Google Scholar
Shroff R, Shanahan C. The vascular biology of calcification. Semin Dial. 2007;20:103–09.
See Also
Frontiers | Effects of vitamin K supplementation on vascular calcification in chronic kidney disease: A systematic review and meta-analysis of randomized controlled trials Vitamin K and vascular calcification in chronic kidney... : Tzu Chi Medical Journal Despite hopes, vitamin K2 supplements fail to slow calcium buildup in heart valve Vitamin K Deficiency and Vascular Calcification. Is There Any Evidence about Its Impact on Coronary Artery Disease?
Article Google Scholar
Delanaye P, Krzesinski JM, Warling X, Moonen M, Smelten N, Médart L, et al. Dephosphorylated- uncarboxylated Matrix Gla protein concentration is predictive of vitamin K status and is correlated with vascular calcification in a cohort of hemodialysis patients. BMC Nephrol. 2014;15:145.
Article Google Scholar
Schurgers J, Cranenburg C, Vermeer C. Matrix Gla protein: the calcification inhibitor in need of vitamin K. Thromb Haemost. 2008;100:593–603.
Article CAS Google Scholar
Berkner K, Runge K. The physiology of vitamin K nutriture and vitamin K-dependent protein function in atherosclerosis. J Thromb Haemost. 2004;2:2118–32.
Article CAS Google Scholar
Schurgers J, Teunissen J, Hamulyak K, Knapen M, Vik H, Vermeer C. Vitamin K-containing dietary supplements: comparison of synthetic vitamin K1 and natto-derived menaquinone-7. Blood. 2007;109:3279–83.
Article CAS Google Scholar
Malyszko J, Wolczynski S, Skrzydlewska E, Małyszko J, Myśliwiec M. Vitamin K status in relation to bone metabolism in patients with renal failure. Am J Nephrol. 2002;22:504–08.
Article Google Scholar
Kalantar-Zadeh K, Kovesdy CP. Clinical outcomes with active versus nutritional vitamin D compounds in chronic kidney disease. Clin J Am Soc Nephrol. 2009;4:1529–39.
Article CAS Google Scholar
Kovesdy CP, Ahmad Zadeh S, Anderson JE, Kalantar- Zadeh K. Association of activated vitamin D treatment and mortality in chronic kidney disease. Arch Intern Med. 2008;168:397–403.
See Also
Can Vitamin K2 Dissolve Kidney Stones? | Dr. Berg
Article CAS Google Scholar
Gonz´alez EA, Sachdeva A, Oliver A, Martin KJ. Vitamin D insufficiency and deficiency in chronic kidney disease: a single center observational study. Am J Nephrol. 2004;24:503–10.
Article Google Scholar
Kim SM, Choi HJ, Lee JP, Kim DK, Oh YK, Kim YS, et al. Prevalence of vitamin D deficiency and effects of supplementation with cholecalciferol in patients with chronic kidney disease. J Ren Nutr. 2014;24:20–25.
Article CAS Google Scholar
Do-Houn K, Cesar AM, Holly C, Jeong-Su K, Robert CH. Vitamin D and endothelial function. Nutrients. 2020;12:575. 10.3390
Article Google Scholar
Mario C, Michela M, Andrea G, Paola C, Piergiorgio M, Sagar N. Vitamin K in chronic kidney disease. Nutrients. 2019;11:168. 10.3390
Article Google Scholar
Su Mi L, Won Suk A. Supplementary nutrients for prevention of vascular calcification in patients with chronic kidney disease. Korean J Intern Med. 2019;34:459–69.
Article Google Scholar
Caluwé R, Vandecasteele S, Van Vlem B, Vermeer C, De Vriese A. Vitamin K2 supplementation in haemodialysis patients: a randomized dose-finding study. Nephrol Dial Transpl. 2014;29:1385–90.
Article Google Scholar
Bentkowski W, Kuzniewski M, Fedak D, Dumnicka P, Kuśnierz-Cabala B, Janda K, et al. Undercarboxylated osteocalcin (Glu-OC) bone metabolism and vascular calcification in hemodialyzed patients. Prz Lek. 2013;70:703–06.
Google Scholar
Holden RM, Morton AR, Garland JS, Pavlov A, Day A, Booth S. Vitamins K and D status in stages 3–5 chronic kidney disease. CJASN. 2010;5:590–97.
Article CAS Google Scholar
Pilkey RM, Morton AR, Boffa MB, Noordhof C, Day A, Su Y, et al. Subclinical vitamin K deficiency in hemodialysis patients. Am J Kidney Dis. 2007;49:432–39.
Article CAS Google Scholar
Westenfeld R, Krueger T, Schlieper G, Cranenburg E, Magdeleyns E, Heidenreich S, et al. Effect of vitamin K2 supplementation on functional vitamin K deficiency in hemodialysis patients: a randomized trial. Am J Kidney Dis. 2012;59:186–95.
Article CAS Google Scholar
Kurnatowska I, Grzelak P, Masajtis-Zagajewska A, Kaczmarska M, Stefańczyk L, Vermeer C, et al. Effect of vitamin K2 on progression of atherosclerosis and vascular calcification in nondialyzed patients with chronic kidney disease stages 3–5. Pol Arch Med Wewn. 2015;125:631–40.
PubMed Google Scholar
Aoun M, Makki M, Azar H, Matta H, Chelala D. High dephosphorylated- uncarboxylated MGP in hemodialysis patients: risk factors and response to vitamin K2, A pre-post intervention clinical trial. BMC Nephrol. 2017;18:191.
Article Google Scholar
Oikonomaki T, Papasotiriou M, Ntrinias T, Kalogeropoulou C, Zabakis P, Kalavrizioti D, et al. The effect of vitamin K2 supplementation on vascular calcification in hemodialysis patients: a 1-year follow-up randomization trial. Int Urol Nephrol. 2019;51:2037–44.
Article Google Scholar

Download references